Next Generation IEX Column Technology

Non-Porous Polymeric Particles

  • Non-porous polymeric particles minimize analyte band spread and enhance mAb separations
  • Optimal sulfonic acid ligand grafting and hydrophilic surface chemistry for superior component recovery, peak shape, and resolution
  • A 3 μm particle size affording columns with low backpressures amenable to use on UPLC, UHPLC or HPLC systems
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BioResolve SCX particle

Featured Application Notes

Designing High-Pressure Capable, Corrosion-Resistant Columns for Cation-Exchange Chromatography

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VanGuard FIT: A Breakthrough in Guard Performance for Challenging Chromatographic Separations

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Designing a New Particle Technology for Robust Charge Variant Analysis of mAbs

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Development of pH Gradient Mobile Phase Concentrates for Robust, High Resolution mAb Charge Variant Analysis

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Development of Monoclonal Antibody Charge Variant Analysis Methods Using a BioResolve SCX mAb Column

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Auto•Blend Plus Technology for Ion-Exchange Chromatography Method Development and Robustness Testing

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Charge-Variant Analysis of Antibody-Drug Conjugates with Cation-Exchange Chromatography

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Scientific Publications

IEX Chromatography Leading the Charge in Charge Variant Analysis
Technology Networks
Mar 14, 2019

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Innovations in Ion-Exchange Chromatography for mAb Variant Analysis
The Column. 2019, 15 (2), 22-25.

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Biosimilar Surge Driving Need for Antibody Characterization
Technology Networks. Feb 06, 2019

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Webinars

Approaches to mAb Charge Variant Characterization using On-Line CEX-MS and Off-Line Analysis of CEX Purified Variants
BioPharm International Webinar sponsored by Waters

Presenters: Samantha Ippoliti, Senior Scientist, Waters Corporation and Stephan Koza, Consulting Scientist, Waters Corporation

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Advances in IEX for mAb Charge Variant Analysis
BioPharm International Webinar sponsored by Waters

Presenters: Qi Wang, Ph.D., Senior Scientist, Waters Corporation and Hua Yang, Ph.D., Principal Scientist, Waters Corporation

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