BioResolve SCX mAb Consumables
An inclusive solution (columns, standards, and pH concentrates) for scientists who need to characterize, monitor, and QC charge variants of mAb-based therapeutics during discovery, development, and manufacturing. Simple to implement, easy to transfer, and does not sacrifice performance or reproducibility.
- BioResolve SCX mAb, 3 μm Columns
- Based on a non-porous, 3 μm particle for optimal diffusion kinetics
- High pressure tolerance
- Amenability to HPLC, UHPLC, and UPLC systems
- VanGuard FIT (Fully Integrated Technology) Cartridge
- Provides ease-of-use without sacrificing performance
- Ensures maximum column lifetime
- Learn More
- BioResolve CX pH Buffer Concentrates
- Carefully optimized pH 5.0 to 10.2 gradients for use with BioResolve SCX mAb Columns to achieve high resolution and robust separations
- Patent-pending, pH gradient mobile phase
- 100 mL 10x concentrates for the preparation of mobile phase using a simple 10-fold water dilution
- mAb Charge Variant Standard
- Unique mix of intact proteins: tryptophan, conalbumin, and the NIST RM 8671 (NIST mAb) to help ensure batch-to-batch consistency
- The QC standard for BioResolve SCX mAb Columns
Care & Use Manuals
Next Generation IEX Column Technology
Non-Porous Polymeric Particles
- Non-porous polymeric particles minimize analyte band spread and enhance mAb separations
- Optimal sulfonic acid ligand grafting and hydrophilic surface chemistry for superior component recovery, peak shape, and resolution
- A 3 μm particle size affording columns with low backpressures amenable to use on UPLC, UHPLC or HPLC systems
Featured Application Notes
Designing High-Pressure Capable, Corrosion-Resistant Columns for Cation-Exchange Chromatography
VanGuard FIT: A Breakthrough in Guard Performance for Challenging Chromatographic Separations
Designing a New Particle Technology for Robust Charge Variant Analysis of mAbs
Development of pH Gradient Mobile Phase Concentrates for Robust, High Resolution mAb Charge Variant Analysis
Development of Monoclonal Antibody Charge Variant Analysis Methods Using a BioResolve SCX mAb Column
Auto•Blend Plus Technology for Ion-Exchange Chromatography Method Development and Robustness Testing
Charge-Variant Analysis of Antibody-Drug Conjugates with Cation-Exchange Chromatography
Scientific Publications
IEX Chromatography Leading the Charge in Charge Variant Analysis
Technology Networks
Mar 14, 2019
Innovations in Ion-Exchange Chromatography for mAb Variant Analysis
The Column. 2019, 15 (2), 22-25.
Biosimilar Surge Driving Need for Antibody Characterization
Technology Networks. Feb 06, 2019
Webinars
Approaches to mAb Charge Variant Characterization using On-Line CEX-MS and Off-Line Analysis of CEX Purified Variants
BioPharm International Webinar sponsored by Waters
Presenters: Samantha Ippoliti, Senior Scientist, Waters Corporation and Stephan Koza, Consulting Scientist, Waters Corporation
Advances in IEX for mAb Charge Variant Analysis
BioPharm International Webinar sponsored by Waters
Presenters: Qi Wang, Ph.D., Senior Scientist, Waters Corporation and Hua Yang, Ph.D., Principal Scientist, Waters Corporation
